ANTHOCLEISTA VOGELII PDF

Discussions Studies of the antiplasmodial effect of A. The choice of these plants was based on previous reports of their antiplasmodial property [ 30 , 31 ]. Again, the remarkable activity of quinine and other related drugs and the success of artemisinin stimulated the search for new plant derived antimalarial drugs [ 19 ]. However, reported cases of drug resistance to these drugs made the search and development of alternative antimalarial drugs inevitable [ 32 ].

Author:Kazragore Tygotaxe
Country:Solomon Islands
Language:English (Spanish)
Genre:Technology
Published (Last):27 January 2007
Pages:407
PDF File Size:3.83 Mb
ePub File Size:7.37 Mb
ISBN:991-2-34143-290-6
Downloads:45294
Price:Free* [*Free Regsitration Required]
Uploader:Samukora



Discussions Studies of the antiplasmodial effect of A. The choice of these plants was based on previous reports of their antiplasmodial property [ 30 , 31 ]. Again, the remarkable activity of quinine and other related drugs and the success of artemisinin stimulated the search for new plant derived antimalarial drugs [ 19 ].

However, reported cases of drug resistance to these drugs made the search and development of alternative antimalarial drugs inevitable [ 32 ]. Phytochemical analysis of the stem bark extract of A. These phytochemicals were previously reported by [ 19 , 33 , 34 ]. These phytochemical compounds were also reported in another species, A.

The presence of similar phytochemicals was recorded in A. These constituents have been found in other natural products which exhibited antimalarial activity [ 36 ]. Plants that contain many phytochemicals with biological activities including alkaloids and flavonoids could serve as sources of antimalarial drugs [ 37 ].

Therefore, the antiplasmodial activity of A. The ethanolic stem bark extract of A. The LD50 of ethanolic stem bark of A. This indicated that the mice were safe with the different doses of the ethanolic stem extracts administered to them.

Similar result was recorded using the methanolic stem bark extract of another species of the plant, A. Similar result was reported within 30 minutes to 1 hour after administration of the ethanolic leaf extract of another species of the plant, A. The results implied that the ethanolic stem bark of A. Parasitaemia in the infected mice was monitored in all the groups using thick and thin blood films made from the tail vein of the mice.

The percentage average parasitaemia showed high level of infection in all the groups after five days of inoculation of P. This result is consistent with previous reports of high percentage parasitaemia in P. The high level of parasitaemia is an important feature of Plasmodium infection which could result in severe anaemia. The starting parasitaemia for the three replicates B1, B2, and B3 before administration of ethanolic stem bark extracts of A.

After administration of extract, the results obtained from the present study showed that the ethanolic stem bark extract of A. This result suggested that the extract possesses some active phytochemical compounds that have direct effects on the parasites and the effect is dose-dependent [ 19 ]. The chemosuppressive activity of These results are indication that plants of the genus Anthocleista possess phytochemical constituents that have antiparasitic property.

The mechanism of action of these extracts of Anthocleista species was however said to be similar to that of chloroquine, a standard antimalarial drug which induced the destruction of the asexual forms of the Plasmodium parasite [ 42 ]. This does not however rule out the chloroquine resistance to the Plasmodium species of mammals. Moreover, the fact that some rural settlements in Africa still rely more on the use of medicinal plants for the treatment of malaria led to the identification of A.

Conclusion The result obtained in this study showed that ethanolic extract of the stem bark of A. This plant can be recommended for use since it possessed a high chemosuppressive effect against the malaria and can be obtained at relatively no cost from the forest.

Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. References 1. World Health Organization.

Severe and complicated malaria. World Health Organisation. World Malaria Report. WHO; The global distribution and population at risk of malaria: past, present, and future. The Lancet Infectious Diseases. Breman JG. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Amsterdam Journal of Tropical Medicine and Hygiene. WHO Sheet. World Health Organisation; Roll back malaria: economic costs of malaria. Economic burden of malaria illness on households versus that of all other illness episodes: a study in five malaria holo-endemic Nigerian communities.

Health Policy. Strategic Plan — Geneva, Switzerland: Mimeograph; Geneva, Switzerland: WHO; Diagnosis practices: malaria diagnosis—new perspective. The roll back malaria strategy for improving access to treatment through home management of malaria.

Alaba A. Malaria and Rural household productivity in Oyo State [Ph. Meleney WP. Control of psoroptic scabies on calves with ivermectin. Amsterdam Journal of Veterinary Research. An in-vitro study of the efficacy of Sevin Inapthyl-methyl carbamate on ectoparasites of livestock. Bulletin of Animal Health Production in Africa. Butenkotter S, Kaemmerer K. The problem of residues in meat of edible domestic animals after application or intake of organophosphate esters.

Residue Research. Health effects of organophosphate sheep dips. Britain Veterinary Journal. A survey of anthelmintic resistance in nematode parasites of goats in Denmark. Veterinary Parasitology. Chema S, Ward D. Cost effective disease control routines and animal health management in animal agriculture. Antiplasmodial and phytochemical investigation of leaf extract of Anthocleista vogelii. Journal of Natural Products. Githens TS. Drug Plants of Africa Handbooks.

Mabogo DEN. The ethnobotany of the Vhavenda [M. Neuwinger HD. African Traditional Medicine. A Dictionary of Plant Use and Applications. Stuttgart, Germany: Medpharm Scientific Publishers; Sofowara A.

Medicinal Plants and Traditional Medicine in Africa. Ibadan, Nigeria: Spectrum Books; Trease A, Evans WC. Trease and Evans Pharmacognosy. London, UK: Bailliere Tindall; Harborne JB. Phytochemical Methods. London, UK: Chapman and Hall; Lorke D. A new approach to practical acute toxicity testing. Archives of Toxicology. Guidelines for the Care and Use of Laboratory Animals. Effects of the aqueous extracts of Alstonia boonei on the haematological profiles of mice experimentally infected with the chloroquine-sensitive strain of P.

Antiprotozoal agents from plant sources. Planta Medica. Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis. Indian Journal of Pharmacology.

The Lancet. Anthocleistenolide, a new rearranged nor-secoiridoid derivative from the stem bark of Anthocleista vogelii.

LASERJET 4050N PDF

Anthocleista vogelii

Please consult your physician or pharmacist or product package for this information. Precautions Please consult your physician or pharmacist or product package for this information. Interactions with Anthocleista Vogelii Please consult your physician or pharmacist or product package for this information. When not to use Anthocleista Vogelii Please consult your physician or pharmacist or product package for this information.

JURNAL VERMIKOMPOS PDF

Anthocleista vogelii Planch.

.

NEWTON TELECOM DICTIONARY PDF

.

CARLOS XUMA SECRETS OF THE ALPHA MAN PDF

.

Related Articles