We suppose that reasons for this contradictory results are associated with the immunohistochemistry technique, in special with the primary antibody employed and with the subjective interpretation and semiquantitative nature of the results. The high percentage of previously observed mucoepiidermoide cases 21 cases, Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site. The mucoepidermoid carcinoma generally shows an extremely aggressive pattern for high-grade tumors, whereas its respectivee low-grade counterpart is often indolent and slow-growing. The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively.
|Published (Last):||14 January 2019|
|PDF File Size:||14.71 Mb|
|ePub File Size:||20.65 Mb|
|Price:||Free* [*Free Regsitration Required]|
No hay notas en la diapositiva. Oncociticos: Mujeres, Ce. HistopathologyMucoepidermoid carcinoma is charac- terized by squamoid epidermoid , mucus producing and cells of intermedi- ate type. The proportion of different cell types and their architectural configura- tion including cyst formation varies in and between tumours.
Overthepasttwodecades, anassociationbetween MEC and t 11;19 q21;p13 translocation has becomewellestablished El-Naggar et al. The genes involved in thistranslocation are mucoepidermoid carcinoma translocated 1 MECT1 onchro- mosome 19p13 and a member of themastermind-like gene family, MAML2, onchromosome 11q Theresultingfusionproteinmay be expressed in alldifferentcelltypesthatconstitutemucoepidermoid carcinoma Cheuk and Chan, Thistranslocationappearstoconfer a favourable prognosis in MEC withfewer local recurrences, metas- tases and tumour-relateddeathscomparedwithfusion-negativepatients Tonon et al.
In our case, thistranslocationwasfound. Conclusiones: Forlow- and intermediate-grade parotid MEC with a pri- marylesionadequatelyexcisedbymeans of subtotal pa- rotidectomy, iftheintraparotidnodes in the superficial lobe are negative, thenthedeeplobe and necknodes do notneedfurthertreatment. Ifanyintraparotidnodeis positive, thedeeplobeshould be addressedwith a con- servative total parotidectomyalongwith a selectiveneckdissection.
Also, a dissection of regional lymphnodeba- sinsshould be performed in cases of suspiciousadenopa- thy and in thosewith more advanced-stage and higher- grade lesions. Whentreated in thisfashion, parotid MEC appearsto be a highly curable disease.
Nonetheless, fol- low-up shouldcontinueforan extended time to rule out late recurrence. Carcinoma mucoepidermoide de glandulas salivales 1. Estadio I. AFIP vs. Estudio retrospectivo de pacientes con CME que recibieron ttr primario o recurrente en elTata Memoria Hospital India durante 19 Eveson, Peter Reichart, David Sidransky.
Mucoepidermoid carcinoma presenting as a large cyst of the parotid gland in HIV disease. Ear NoseThroat J. Mucoepidermoid carcinoma: A yet unreported cancer associated with familial adenomatous polyposis. J Craniomaxillofac Surg. Mucoepidermoid carcinoma of the parotid gland: factors affecting outcome. Head Neck. Mucoepidermoid carcinoma of the parotid gland: the Mayo clinic experience.
Arch Otolaryngol Head Neck Surg.
Tumores de las glándulas salivales
Fenrilmaran International histological classification of tumours. Clinical information about age, gender, and site were obtained from the biopsy records. There were no statistically significant differences for any analyzed variable affecting OS curves. Tumors were stratified into three groups: Sinonasal and maxillary tumors were not included in the sample. High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. Thus, our findings may suggest the lack of association among clinicopathological features and the immunoexpression of c-erbB Blocking of endogenous peroxidase and avidin-biotin activity were performed Miller et al.
No hay notas en la diapositiva. Oncociticos: Mujeres, Ce. HistopathologyMucoepidermoid carcinoma is charac- terized by squamoid epidermoid , mucus producing and cells of intermedi- ate type. The proportion of different cell types and their architectural configura- tion including cyst formation varies in and between tumours. Overthepasttwodecades, anassociationbetween MEC and t 11;19 q21;p13 translocation has becomewellestablished El-Naggar et al.